Roychowdhury says his team is continually humbled by patients’ eagerness to help advance research in any way possible, even if those discoveries will not come in time to eradicate their own disease.
Theme hospital auto autopsy trial#
It is a legacy of hope and exciting to see both precision cancer medicine and the research autopsy trial translating into discoveries at the patient’s bedside.” “We are so humbled by our patients’ selflessness by participating in research that will help others. “This represents a strong potential new therapy option for diseases that have limited treatment options,” Roychowdhury said. Roychowdhury notes this study could provide evidence that more patients with FGFR gene mutations could benefit from new therapy approaches that directly target FGFR. This study was designed and developed by the OSUCCC – James team as an investigator-initiated trial in partnership with the drug development industry. Going beyond cholangiocarcinoma, OSUCCC – James investigators are enrolling patients to a phase 2 study of infigratinib for patients with other cancer types that harbor FGFR gene mutations. Results showed meaningful impact on tumor response and led to the FDA-approval of this therapy for cholangiocarcinoma and these specific FGFR2 fusions in May 2021. The team recently published findings in the medical journal Lancet: Gastroenterology & Hepatology from a single-arm, multicenter, phase 2 study of the drug infigratinib in previously treated patients with locally advanced or metastatic cholangiocarcinoma, a rare and difficult-to-treat form that occurs in the bile duct. This drug targets FGFR2 gene mutations known as fusions in cholangiocarcinoma and other cancer types. Data gathered from these autopsies has already led to novel findings about drug resistance mechanisms for a recently approved, novel targeted therapy called infigratinib (pronounced “IN fig RA ti nib”, marketed as Truseltiq, pronounced “troo-SEL-tik”). Since the trial’s launch in 2016, the OSUCCC – James rapid research autopsy team has performed 55 autopsies. Samples are preserved to “freeze/pause” the tissue characteristics at that moment so that they can go back to the lab and identify potential genetic mutations or cellular characteristics that could explain why therapy stopped working, in hopes of guiding future therapies. When the patient passes, researchers rapidly mobilize to perform an autopsy before tissues degrade. This can help us understand how the cancer cells overcame different treatments and then go back to the drawing board to develop better therapies targeted to different genes and types of cancer.įor this Pelotonia-funded study, patients consent during life to donate biological samples upon death for the purposes of cancer research. “The rapid autopsy program allows us to sample every site of cancer in the body. “As patients undergo cancer treatment and, in some instances, succumb to their disease, there's limited opportunity to understand their cancer and what made it so lethal and what took their lives,” said Roychowdhury, a medical oncologist and researcher with the OSUCCC – James Translational Therapeutics Program. Sameek Roychowdhury, this unique clinical research study – known as the Rapid Cancer Research Autopsy Trial – allows scientists to gather biological samples after a patient’s death to conduct research otherwise not possible, with the goal of better understanding how the cancer cells overcame different treatments. Solove Research Institute (OSUCCC – James) turns cancer scientists into molecular detectives, searching for clues for why certain cancers are able to spread and evolve by studying tissues collected within hours of death. Newswise - COLUMBUS, Ohio – A new research study at The Ohio State University Comprehensive Cancer Center – Arthur G. News Research News Releases Journal News Medical News Science News Life News Business News Expert Pitch Google Fact Check Research Alert Marketplace News With Video/Audio Multimedia RSS Feeds by Latest News Coronavirus News Currently Embargoed
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